DOREA
Dual ORexin antagonism and Emotion and Affective processing study
Key Info
We are looking for healthy volunteers aged between 18 and 40 years for a study investigating the effects of a single dose of a drug called daridorexant on reward, emotional processing and short-term memory. Our study is about how new sleep medications can affect brain processes often altered in depression.
Location
Warneford Hospital, OX3 7JX
Group
Healthy volunteers aged 18-40
Ethics Reference
MS IDREC 582356
What does this involve?
1. Online screening form (~ 5 minutes): You’ll fill out a form to check if you qualify. We’ll ask about you, your health history, medications, lifestyle, and if you participated in similar studies. If you qualify, we’ll ask for your contact details.
2. Online screening video call (~ 45 minutes): A researcher will contact you and you can book an online screening call. We’ll check your suitability for the research, which will involve questions about your medical history and a psychiatric assessment.
3. In-person Screening visit (~ 2 hours): A researcher will contact you and you can book a convenient time for you to come to the Warneford Hospital. We’ll double-check your suitability for the research, including a urine test for drugs and pregnancy. If suitable, you’ll be asked to complete some questionnaires and three computer tasks.
4. In-person Study visit (5 hours): We’ll agree a time for you to come to the Warneford Hospital in the morning. We’ll repeat a few of the screening questions we asked you before. We’ll then give you one (50mg) dose of an insomnia medication called daridorexant or a dummy tablet – you won’t know which. After an hour, you’ll complete some computer-based tasks and questionnaires. It will also involve saliva collection during one of the tasks.
5. Online Follow up (~ 10 minutes): We’ll email you a questionnaire the day after the visit with questions about side effects and your last night’s sleep.
Who are we looking for?
People who are healthy, aged 18-40, with no history of without a history of mental health disorders (like depression) or sleep disorders (like chronic insomnia). You must, in particular, have good English or not be pregnant. You will also need to be able to read without glasses for some computer tasks.
Please note: We will be unable to include you if you have taken part in any other drug studies in the past 3 months, including if you are currently enrolling in one.
We will also be unable to include you if you have taken part in any other PERL studies in the past 6 months, including if you are currently enrolling in one.
How do I learn more?
Click below to express interest or learn more!
What studies am I eligible for?
Check whether you would be eligible for any of our current studies!
You may be asked a few questions about your mood and demographics. All of your responses are completely anonymous and will not be kept on our records.
Thank you for your interest!
If you are experiencing low moods or depression and would like advice or support, please read our mental health support page.